ALLELE-SPECIFIC METHYLATION IN THE FADS GENOMIC REGION IN DNA FROM HUMAN SALIVA, CD4+ CELLS, AND TOTAL LEUKOCYTES

Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes

Abstract Background Genetic variants within the fatty acid desaturase (FADS) gene cluster (human Chr11) are important regulators of long-chain (LC) polyunsaturated fatty acid (PUFA) biosynthesis in the liver and consequently have been associated with circulating LC-PUFA levels.More recently, epigenetic modifications such as DNA methylation, particu

read more



Expression of Integrin β6 and HAX-1 Correlates with Aggressive Features and Poor Prognosis in Esophageal Squamous Cell Carcinoma

Fanni Li,1 Yukui Shang,2 Feiyu Shi,3 Lei Zhang,3 Jun Yan,3 Qi Sun,3 Junjun She3 1Department of Talent Highland, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, People’s Republic of China; 2Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, People’s Republi

read more

Integrative transcriptomic, proteomic, and machine learning approach to identifying feature genes of atrial fibrillation using atrial samples from patients with valvular heart disease

Abstract Background Atrial fibrillation (AF) is the most common arrhythmia with poorly understood mechanisms.We aimed to investigate the biological mechanism of AF and to discover feature genes by analyzing multi-omics data and by applying a machine Ophthalmic learning approach.Methods At the transcriptomic level, four microarray datasets (GSE41177

read more