Allele-specific methylation in the FADS genomic region in DNA from human saliva, CD4+ cells, and total leukocytes
Abstract Background Genetic variants within the fatty acid desaturase (FADS) gene cluster (human Chr11) are important regulators of long-chain (LC) polyunsaturated fatty acid (PUFA) biosynthesis in the liver and consequently have been associated with circulating LC-PUFA levels.More recently, epigenetic modifications such as DNA methylation, particu